Regional brain shrinkage over two years: Individual differences and effects of pro-inflammatory genetic polymorphisms
2014 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 103, 334-348 p.Article in journal (Refereed) Published
We examined regional changes in brain volume in healthy adults (N = 167, age 19–79 years at baseline; N = 90 at follow-up) over approximately two years. With latent change score models, we evaluated mean change and individual differences in rates of change in 10 anatomically-defined and manually-traced regions of interest (ROIs): lateral prefrontal cortex (LPFC), orbital frontal cortex (OF), prefrontal white matter (PFw), hippocampus (Hc), parahippocampal gyrus (PhG), caudate nucleus (Cd), putamen (Pt), insula (In), cerebellar hemispheres (CbH), and primary visual cortex (VC). Significant mean shrinkage was observed in the Hc, CbH, In, OF, and PhG, and individual differences in change were noted in all regions, except the OF. Pro-inflammatory genetic variants modified shrinkage in PhG and CbH. Carriers of two T alleles of interleukin-1β (IL-1β C-511T, rs16944) and a T allele of methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) polymorphisms showed increased PhG shrinkage. No effects of a pro-inflammatory polymorphism for C-reactive protein (CRP-286C>A>T, rs3091244) or apolipoprotein (APOE) ε4 allele were noted. These results replicate the pattern of brain shrinkage observed in previous studies, with a notable exception of the LPFC, thus casting doubt on the unique importance of prefrontal cortex in aging. Larger baseline volumes of CbH and In were associated with increased shrinkage, in conflict with the brain reserve hypothesis. Contrary to previous reports, we observed no significant linear effects of age and hypertension on regional brain shrinkage. Our findings warrant further investigation of the effects of neuroinflammation on structural brain change throughout the lifespan.
Place, publisher, year, edition, pages
2014. Vol. 103, 334-348 p.
Aging, MRI, Inflammation, Longitudinal, Parahippocampal gyrus, Cerebellum, Interleukin-1β
Psychology Neurosciences Radiology, Nuclear Medicine and Medical Imaging
Research subject Psychology
IdentifiersURN: urn:nbn:se:su:diva-108565DOI: 10.1016/j.neuroimage.2014.09.042ISI: 000345393100034OAI: oai:DiVA.org:su-108565DiVA: diva2:759380
This research was supported by the National Institute on Aging grant R37 AG-11230 to NR. NP was supported by grants FOA11H-090, FOA13H-090, FO2011-0504 and FO2013-0189 from the Swedish Royal Academia of Sciences, Lars Hiertas Memorial Foundation, Solstickan Foundation and Department of Psychology at the Stockholm University (Ann-Charlotte Smedler, Head of the Department). We acknowledge Awantika Deshmukh's contribution to tracing of the ROIs.2014-10-292014-10-292015-12-02Bibliographically approved