The Browning of White Adipose Tissue: Some Burning Issues
2014 (English)In: Cell Metabolism, ISSN 1550-4131, E-ISSN 1932-7420, Vol. 20, no 3, 396-407 p.Article, review/survey (Refereed) Published
Igniting thermogenesis within white adipose tissue (i.e., promoting expression and activity of the uncoupling protein UCP1) has attracted much interest. Numerous browning agents'' have now been described (gene ablations, transgenes, foodcomponents, drugs, environments, etc.). The implied action of browning agents is that they increase UCP1 through this heat production, leading to slimming. Here, we particularly point to the possibility that cause and effect may on occasion be the reverse: browning agents may disrupt, for example, the fur, leading to increased heat loss, increased thermogenic demand to counteract this heat loss, and thus, through sympathetic nervous system activation, to enhanced UCP1 expression in white (and brown) adipose tissues.
Place, publisher, year, edition, pages
2014. Vol. 20, no 3, 396-407 p.
IdentifiersURN: urn:nbn:se:su:diva-108208DOI: 10.1016/j.cmet.2014.07.005ISI: 000341402800006OAI: oai:DiVA.org:su-108208DiVA: diva2:760312