The role of NADPH oxidase (NOX) enzymes in neurodegenerative disease
2013 (English)In: Frontiers in Biology, ISSN 1674-7992, Vol. 8, no 2, 175-188 p.Article in journal (Refereed) Published
Recently, mounting evidence implicating reactive oxygen species (ROS) generated by NADPH oxidase(NOX) enzymes in the pathogenesis of several neurodegenerative diseases including Amyotrophic lateral sclerosis(ALS), Alzheimer’s (AD), Parkinson’s (PD) and polyglutamine disease, have arisen. NOX enzymes are transmembraneproteins and generate reactive oxygen species by transporting electrons across lipid membranes. Under normal healthyconditions, low levels of ROS produced by NOX enzymes have been shown to play a role in neuronal differentiation andsynaptic plasticity. However, in chronic neurodegenerative diseases over-activation of NOX in neurons, as well as inastrocytes and microglia, has been linked to pathogenic processes such as oxidative stress, exitotoxicity andneuroinflammation. In this review, we summarize the current knowledge about NOX functions in the healthy centralnervous system and especially the role of NOX enzymes in neurodegenerative disease processes.
Place, publisher, year, edition, pages
2013. Vol. 8, no 2, 175-188 p.
Chemical Sciences Biological Sciences
Research subject Neurochemistry with Molecular Neurobiology
IdentifiersURN: urn:nbn:se:su:diva-108884DOI: 10.1007/s11515-012-1250-yOAI: oai:DiVA.org:su-108884DiVA: diva2:761300
FunderSwedish Research Council