Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The role of NADPH oxidase (NOX) enzymes in neurodegenerative disease
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-9064-5432
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-9834-4554
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0002-8630-2127
2013 (English)In: Frontiers in Biology, ISSN 1674-7992, Vol. 8, no 2, 175-188 p.Article in journal (Refereed) Published
Abstract [en]

Recently, mounting evidence implicating reactive oxygen species (ROS) generated by NADPH oxidase(NOX) enzymes in the pathogenesis of several neurodegenerative diseases including Amyotrophic lateral sclerosis(ALS), Alzheimer’s (AD), Parkinson’s (PD) and polyglutamine disease, have arisen. NOX enzymes are transmembraneproteins and generate reactive oxygen species by transporting electrons across lipid membranes. Under normal healthyconditions, low levels of ROS produced by NOX enzymes have been shown to play a role in neuronal differentiation andsynaptic plasticity. However, in chronic neurodegenerative diseases over-activation of NOX in neurons, as well as inastrocytes and microglia, has been linked to pathogenic processes such as oxidative stress, exitotoxicity andneuroinflammation. In this review, we summarize the current knowledge about NOX functions in the healthy centralnervous system and especially the role of NOX enzymes in neurodegenerative disease processes.

Place, publisher, year, edition, pages
2013. Vol. 8, no 2, 175-188 p.
National Category
Chemical Sciences Biological Sciences
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-108884DOI: 10.1007/s11515-012-1250-yOAI: oai:DiVA.org:su-108884DiVA: diva2:761300
Funder
Swedish Research Council
Available from: 2014-11-06 Created: 2014-11-06 Last updated: 2015-08-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Ajayi, AbiodunYu, XinStröm, Anna-Lena
By organisation
Department of Neurochemistry
Chemical SciencesBiological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 177 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf