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Radiobiological treatment planning evaluation of inverse planning simulated annealing for cervical cancer high-dose-rate brachytherapy
Stockholm University, Faculty of Science, Department of Physics. Eduardo Mondlane University, Mozambique.
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2015 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 35, no 2, 935-939 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To compare five inverse treatment plans with one conventional manually optimized plan for cervical cancer brachytherapy (BT) using radiobiological parameters combined with dosimetric and volumetric parameters.

Materials and Methods: Five inverse treatment plans were calculated using an inverse planning simulated annealing (IPSA) algorithm for each of four fractions for 12 cervical cancer patients treated with high-dose-rate (HDR) brachytherapy. The inverse treatment plans were compared with a manually optimized plan used for the actual treatment of the patients. The comparison of the plans was performed with respect to the probability of cure without complication.

Results: Overall, the manually optimized plan scored the best results; however, the probability of cure without complication is within an acceptable clinical range for all the plans.

Conclusion: Although there are still considerable uncertainties in the radiobiological parameters, the radiobiological plan evaluation method presents itself as a potential complement to physical dosimetric methods.

Place, publisher, year, edition, pages
2015. Vol. 35, no 2, 935-939 p.
Keyword [en]
Brachytherapy, IPSA, radiobiological evaluation
National Category
Cancer and Oncology
URN: urn:nbn:se:su:diva-109064ISI: 000349598600041OAI: diva2:762190
Available from: 2014-11-10 Created: 2014-11-10 Last updated: 2016-05-03Bibliographically approved
In thesis
1. Optimization of brachytherapy for cervical cancer using inverse planning algorithms.
Open this publication in new window or tab >>Optimization of brachytherapy for cervical cancer using inverse planning algorithms.
2015 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Carcinoma of the cervix is a global problem. Brachytherapy (BT) is one of the main

radiation therapy components used in the management of cervical cancer. With the

advent of scientific and technological developments in treatment planning, inverse optimization

in BT has been imposed; however, to harness the full potential of inverse

planning in brachytherapy, its thorough comparison with manual optimization methods

is warranted.

Although inverse optimization algorithms are based on different mathematical approaches,

their goals are similar. The underlying principles of these algorithms will

allow them to be applied with the aim of respecting normal structures absorbed dose

limits while delivering high enough tumouricidal dose.

In this work, the physical parameters minimum dose received by 98% and 90% of

the target volume represented by D98 and D90, respectively, were used to evaluate the

treatment plans with respect to the target while the minimum dose received by 2cm3

volume, D2cm3 , was used to investigate complications in organs at risk (OARs). The

conformity index (COIN), was used to describe the coverage of the target by the prescribed

dose (PD) and the fraction of each OAR volume that receives a critical dose,

which may cause complication. The treatment plan evaluation was also performed

in terms of the complication-free tumour control probability, P+. The physical and

radiobiological evaluation corresponding to plans obtained by the inverse planning

simulated annealing algorithm (IPSA) and the hybrid inverse planning optimization

(HIPO) have been compared with corresponding ones for plans obtained using a manual

graphical optimization method.

The main observations of this work are that well tuned class solutions of inverse

optimization methods are able to produce similar dose volume histograms to those

produced with manual graphical optimization and inverse methods have the potential

to spare organs at risk while delivering acceptable dose to the target. In addition, radiobiological

indexes such as the P+ can be useful complements to physical parameters

in treatment plan evaluation.

Place, publisher, year, edition, pages
Stockholms universitets förlag, 2015
Brachytherapy, treatment planning optimization, IPSA, HIPO, radiobiology, complicationfree
National Category
Physical Sciences
Research subject
Medical Radiation Physics
urn:nbn:se:su:diva-121548 (URN)
Available from: 2016-05-03 Created: 2015-10-07 Last updated: 2016-05-03Bibliographically approved

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Toma-Dasu, Iuliana
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