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Chronic low-grade inflammation in metabolic disorders: relevance for behavioral symptoms.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. (Psychoneuroimmunology)
2014 (English)In: Neuroimmunomodulation, ISSN 1021-7401, E-ISSN 1423-0216, Vol. 21, no 2-3, 95-101 p.Article in journal (Refereed) Published
Abstract [en]

The ability of cytokines to influence cerebral functions and to induce the development of behavioral alterations is well established in conditions of acute or chronic high-grade activation of the innate immune system. Recent evidence suggests that the release of these immune mediators during chronic low-grade endogenous inflammatory processes may also contribute to the development of behavioral alterations. Metabolic disorders, including obesity, type 2 diabetes and the metabolic syndrome, represent examples of those conditions which are both characterized by a chronic low-grade inflammatory state and an increased prevalence of behavioral disorders. In metabolic disorders, the increased production of acute-phase proteins and cytokines (e.g. C-reactive protein, interleukin-6 and tumor necrosis factor-α), but at relatively low levels, may promote and contribute to the development of behavioral symptoms, including depressive symptoms, cognitive impairment, fatigue, sleep problems and pain. This hypothesis is supported by a growing literature referring both to experimental and clinical findings that will be reviewed here.

Place, publisher, year, edition, pages
Basel: S. Karger, 2014. Vol. 21, no 2-3, 95-101 p.
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Other Basic Medicine
URN: urn:nbn:se:su:diva-109382DOI: 10.1159/000356535PubMedID: 24557041Local ID: P-3174OAI: diva2:764683
Available from: 2014-11-20 Created: 2014-11-20 Last updated: 2014-11-20Bibliographically approved

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