Tandem alpha-Alkylation/Asymmetric Transfer Hydrogenation of Acetophenones with Primary Alcohols
2014 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 30, 6639-6642 p.Article in journal (Refereed) Published
A tandem -alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and with use of [Ru(p-cymene)Cl-2](2) in combination with an amino acid hydroxyamide ligand, the chiral secondary alcohol products were isolated in moderate yields and in moderate to good enantiomeric excess (up to 89% ee).
Place, publisher, year, edition, pages
2014. no 30, 6639-6642 p.
Alkylation, Amino acids, Asymmetric catalysis, Reduction, Ruthenium
IdentifiersURN: urn:nbn:se:su:diva-109980DOI: 10.1002/ejoc.201403032ISI: 000343872900007OAI: oai:DiVA.org:su-109980DiVA: diva2:768398
FunderKnut and Alice Wallenberg FoundationSwedish Research Council