CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages
2014 (English)In: Cell reports, ISSN 2211-1247, Vol. 9, no 3, 1075-1088 p.Article in journal (Refereed) Published
The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. The analysis identified a conserved CD161++/MAIT cell transcriptional signature enriched in CD161+CD8+ T cells, which can be extended to CD161+ CD4+ and CD161+TCR gamma delta+ T cells. Furthermore, this led to the identification of a shared innate-like, TCR-independent response to interleukin (IL)-12 plus IL-18 by different CD161-expressing T cell populations. This response was independent of regulation by CD161, which acted as a costimulatory molecule in the context of T cell receptor stimulation. Expression of CD161 hence identifies a transcriptional and functional phenotype, shared across human T lymphocytes and independent of both T cell receptor (TCR) expression and cell lineage.
Place, publisher, year, edition, pages
2014. Vol. 9, no 3, 1075-1088 p.
IdentifiersURN: urn:nbn:se:su:diva-110749DOI: 10.1016/j.celrep.2014.09.045ISI: 000344470000028OAI: oai:DiVA.org:su-110749DiVA: diva2:773223