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Serum metabolomic biomarkers of dementia.
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2014 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 4, no 2, 252-262 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: This study compared serum metabolites of demented patients (Alzheimer's disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis.

METHODS: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry.

RESULTS: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid.

CONCLUSIONS: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.

Place, publisher, year, edition, pages
2014. Vol. 4, no 2, 252-262 p.
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URN: urn:nbn:se:su:diva-112162DOI: 10.1159/000364816PubMedID: 25177334OAI: diva2:779106
Available from: 2015-01-12 Created: 2015-01-09 Last updated: 2015-01-23Bibliographically approved

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Nilsson, Lars-Göran
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Aging Research Center (ARC), (together with KI)Department of Psychology
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