Porous titania surfaces on titanium with hierarchical macro- and mesoporosities for enhancing cell adhesion, proliferation and mineralization
2015 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, Vol. 47, 376-383 p.Article in journal (Refereed) Published
Titanium received a macroporous titania surface layer by anodization, which contains open pores with average pore diameter around 5 gm. An additional mesoporous titania top layer following the contour of the macropores, of 100-200 nm thickness and with a pore diameter of 10 nm, was formed by using the evaporation-induced self-assembly (EISA) method with titanium (IV) tetraethoxide as the precursor. A coherent laminar titania surface layer was thus obtained, creating a hierarchical macro- and mesoporous surface that was characterized by high-resolution electron microscopy. The interfacial bonding between the surface layers and the titanium matrix was characterized by the scratch test that confirmed a stable and strong bonding of titania surface layers on titanium. The wettability to water and the effects on the osteosarcoma cell line (SaOS-2) proliferation and mineralization of the formed titania surface layers were studied systematically by cell culture and scanning electron microscopy. The results proved that the porous titania surface with hierarchical macro- and mesoporosities was hydrophilic that significantly promoted cell attachment and spreading. A synergistic role of the hierarchical macro- and mesoporosities was revealed in terms of enhancing cell adhesion, proliferation and mineralization, compared with the titania surface with solo scale topography.
Place, publisher, year, edition, pages
2015. Vol. 47, 376-383 p.
Porosity, Titanium oxide, Cell adhesion, Cell proliferation, Surface topography
Research subject Materials Chemistry
IdentifiersURN: urn:nbn:se:su:diva-112844DOI: 10.1016/j.msec.2014.11.021ISI: 000347581600045OAI: oai:DiVA.org:su-112844DiVA: diva2:781501