Peptide-based vectors: recent developments
2014 (English)In: Biomolecular Concepts, ISSN 1868-503X, Vol. 5, no 6, 479-488 p.Article in journal (Refereed) Published
Peptides and peptide-cargo complexes have been used for drug delivery and gene therapy. One of the most used delivery vectors are cell-penetrating peptides, due to their ability to be taken up by a variety of cell types and deliver a large variety of cargoes through the cell membrane with low cytotoxicity. In vitro and in vivo studies have shown their possibility and full effectiveness to deliver oligonucleotides, plasmid DNA, small interfering RNAs, antibodies, and drugs. We report in this review some of the latest strategies for peptide-mediated delivery of nucleic acids. It focuses on peptide-based vectors for therapeutic molecules and on nucleic acid delivery. In addition, we discuss recent applications and clinical trials.
Place, publisher, year, edition, pages
2014. Vol. 5, no 6, 479-488 p.
cell-penetrating peptide, delivery vector, nucleic acid, oligonucleotide delivery, peptide
Research subject Neurochemistry with Molecular Neurobiology
IdentifiersURN: urn:nbn:se:su:diva-113634DOI: 10.1515/bmc-2014-0024PubMedID: 25429600OAI: oai:DiVA.org:su-113634DiVA: diva2:786506