Change search
ReferencesLink to record
Permanent link

Direct link
Predicting Long-Term Outcome of Cognitive Behaviour Therapy for Social Anxiety Disorder Using fMRI and Support Vector Machiness
Show others and affiliations
2014 (English)In: Abstracts from the 44th Congress of the European Association for Behavioural & Cognitive Therapies, 2014Conference paper, Abstract (Refereed)
Abstract [en]

Background: Cognitive behavioural therapy (CBT) has yielded robust treatment effects for social anxiety disorder (SAD) but still many patients do not respond fully to treatment, and a substantial proportion relapse after treatment has ended. Identification of robust predictors of sustained treatment responses could be of high clinical importance.

Methods: We used functional magnetic resonance imaging (fMRI; 3T General Electric) to assess 26 patients (85% women, mean age 32.3 years) with SAD. Blood-oxygen-level dependent (BOLD) responses to self-referential criticism, i.e. reading sentences such as "Nobody likes you" were compared to criticism referring to other individuals. Responses in the fear network, i.e. the amygdala, hippocampus, anterior cingulate cortex (ACC), and insula, were evaluated in a Support Vector Machine (SVM) approach to predict treatment outcome one-year after Internet-delivered CBT. We applied leave-one-out cross-validation to increase the generalizability of the data.

Results: At one-year follow-up, three patients had dropped out. Twelve (52%) of the assessed patients met the response criteria, i.e. very much or much improved according to the Clinical Global Impression-Improvement scale (CGI-I). SVM on initial BOLD response, accurately classified patients according to responder status, based on multi-voxel patterns in the ACC (balanced accuracy of 91.7%, p=.001), and the ACC together with the amygdala (83.0%, p=.004) as well as the hippocampus (73.9%,p=.032).

Conclusions: We demonstrate that initial multi-voxel BOLD response patterns to self-referential criticism in the ACC, amygdala, and hippocampus are highly predictive of long-term improvement of CBT in patients with SAD.

Place, publisher, year, edition, pages
Keyword [en]
long-term outcomes, CBT, SAD, fMRI, SVM
National Category
Research subject
URN: urn:nbn:se:su:diva-113641OAI: diva2:786524
EABCT 2014: 44th Congress of the European Association for Behavioural & Cognitive Therapies, September 10-13, 2014, The Hague, The Netherlands.
Available from: 2015-02-05 Created: 2015-02-05 Last updated: 2015-02-16Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Carlbring, Per
By organisation
Department of Psychology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 243 hits
ReferencesLink to record
Permanent link

Direct link