Quantification of neurotoxin BMAA (beta-N-methylamino-L-alanine) in seafood from Swedish markets
2014 (English)In: Scientific Reports, ISSN 2045-2322, Vol. 4, 6931- p.Article in journal (Refereed) Published
The neurotoxin beta-N-methylamino-L-alanine (BMAA) produced naturally by cyanobacteria, diatoms and dinoflagellates can be transferred and accumulated up the food chain, and may be a risk factor for neurodegenerative diseases. This study provides the first systematic screening of BMAA exposure of a large population through the consumption of seafood sold in metropolitan markets. BMAA was distinguished from known isomers by liquid chromatography tandem mass spectrometry after acidic hydrolysis and derivatization. Using deuterium-labeled internal standard, BMAA was quantified as 0.01-0.90 mu g/g wet weight of tissues in blue mussel, oyster, shrimp, plaice, char and herring, but was undetectable (<0.01 mu g/g) in other samples (salmon, cod, perch and crayfish). Provided that the content of BMAA detected is relevant for intake calculations, the data presented may be used for a first estimation of BMAA exposure through seafood from Swedish markets, and to refine the design of future toxicological experiments and assessments.
Place, publisher, year, edition, pages
2014. Vol. 4, 6931- p.
Research subject Analytical Chemistry
IdentifiersURN: urn:nbn:se:su:diva-110174DOI: 10.1038/srep06931ISI: 000344315200003OAI: oai:DiVA.org:su-110174DiVA: diva2:787274