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Metals as a Common Trigger of Inflammation Resulting in Non-Specific Symptoms: Diagnosis and Treatment
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
2014 (English)In: Israel Medical Association Journal, ISSN 1565-1088, Vol. 16, no 12, 753-758 p.Article in journal (Refereed) Published
Abstract [en]

Background: The multiple symptoms of chronic fatigue syndrome (CFS) and fibromyalgia resemble those described in patients suffering from autoimmune/inflammatory syndrome induced by adjuvants (ASIA). It has been suggested that chronic metal-induced inflammation might play a role both in CFS and fibromyalgia as well as in ASIA. Humans are exposed to metal Mainly through the release of metal ions from corroding dental restorations and orthopedic implants, food, Vaccines and jewelry. Metals readily bind to sulphur and other groups in the mitochondria, enzymes and cell proteins. Metal-bound proteins are recognized by the immune system of susceptible subjects and might trigger an abnormal immune response, including allergy and autoimmunity. Objectives: To study three subjects with CFS and two with fibromyalgia, all cif whom suspected metal exposure as a trigger for their ill health. Methods: We measured delayed-type hypersensitivity to metals (metal allergy) using a validated lymphocyte transformation test, LTT-MELISA (R). All patients except one were sensitized to metals present in their dental restorations. The remaining patient reacted to metals in his Skull implant. The removal a sensitizing metals resulted in long-term health improvement. Nine healthy controls matched for gender and age showed only marginal reactivity to the metals tested. Conclusions: Patients with CFS and fibromyalgia are frequently sensitized to metals found in the environment or used in dentistry and surgery. This allergy to metals Might initiate or aggravate non-specific symptoms in metal-sensitized patients.

Place, publisher, year, edition, pages
2014. Vol. 16, no 12, 753-758 p.
Keyword [en]
metal allergy, LTT-MELISA, chronic fatigue syndrome (CFS), fibromyalgia, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), nickel allergy
National Category
Microbiology in the medical area Immunology in the medical area
URN: urn:nbn:se:su:diva-113709ISI: 000347503900004OAI: diva2:796335


Available from: 2015-03-18 Created: 2015-02-09 Last updated: 2015-03-18Bibliographically approved

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