Change search
ReferencesLink to record
Permanent link

Direct link
Putative adverse outcome pathways relevant to neurotoxicity
Show others and affiliations
2015 (English)In: Critical reviews in toxicology, ISSN 1040-8444, E-ISSN 1547-6898, Vol. 45, no 1, 83-91 p.Article, review/survey (Refereed) Published
Abstract [en]

The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs). The AOP starts with an molecular initiating event (MIE) in which a chemical interacts with a biological target(s), followed by a sequential series of KEs, which are cellular, anatomical, and/or functional changes in biological processes, that ultimately result in an AO manifest in individual organisms and populations. It has been developed as a tool for a knowledge-based safety assessment that relies on understanding mechanisms of toxicity, rather than simply observing its adverse outcome. A large number of cellular and molecular processes are known to be crucial to proper development and function of the central (CNS) and peripheral nervous systems (PNS). However, there are relatively few examples of well-documented pathways that include causally linked MIEs and KEs that result in adverse outcomes in the CNS or PNS. As a first step in applying the AOP framework to adverse health outcomes associated with exposure to exogenous neurotoxic substances, the EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) organized a workshop (March 2013, Ispra, Italy) to identify potential AOPs relevant to neurotoxic and developmental neurotoxic outcomes. Although the AOPs outlined during the workshop are not fully described, they could serve as a basis for further, more detailed AOP development and evaluation that could be useful to support human health risk assessment in a variety of ways.

Place, publisher, year, edition, pages
2015. Vol. 45, no 1, 83-91 p.
Keyword [en]
adverse outcome pathway, in vitro testing, key events, molecular initiating event, pathways of neurotoxicity, predictive toxicology
National Category
Pharmacology and Toxicology Chemical Sciences Biological Sciences
URN: urn:nbn:se:su:diva-114260DOI: 10.3109/10408444.2014.981331ISI: 000348199100005PubMedID: 25605028OAI: diva2:798916


Available from: 2015-03-27 Created: 2015-02-25 Last updated: 2015-09-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Forsby, Anna
By organisation
Department of Neurochemistry
In the same journal
Critical reviews in toxicology
Pharmacology and ToxicologyChemical SciencesBiological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 64 hits
ReferencesLink to record
Permanent link

Direct link