Mild and Selective Et2Zn-Catalyzed Reduction of Tertiary Amides under Hydrosilylation Conditions
2015 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 17, no 3, 446-449 p.Article in journal (Refereed) Published
Diethylzinc (Et2Zn) can be used as an efficient and chemoselective catalyst for the reduction of tertiary amides under mild reaction conditions employing cost-effective polymeric silane (PMHS) as the hydride source. Crucial for the catalytic activity was the addition of a substoichiometric amount of lithium chloride to the reaction mixture. A series of amides containing different additional functional groups were reduced to their corresponding amines, and the products were isolated in good-to-excellent yields.
Place, publisher, year, edition, pages
2015. Vol. 17, no 3, 446-449 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-115688DOI: 10.1021/ol503430tISI: 000349274200014PubMedID: 25587664OAI: oai:DiVA.org:su-115688DiVA: diva2:799618