Cidea improves the metabolic profile through expansion of adipose tissue
(English)Manuscript (preprint) (Other academic)
In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. By generating transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice), we have here established a functional, causative role for Cidea, mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome - perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Together this implies that in humans the association between Cidea levels in white fat and metabolic health is not only correlative but is causative.
Medical and Health Sciences
Research subject Physiology
IdentifiersURN: urn:nbn:se:su:diva-115872OAI: oai:DiVA.org:su-115872DiVA: diva2:800515