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Cognitive outcome varies in adolescents born preterm, depending on gestational age, intrauterine growth and neonatal complications
Stockholm University, Faculty of Social Sciences, Department of Psychology. Karolinska Institutet, Sweden.
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 3, 292-299 p.Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of this study was to investigate long-term cognitive outcome in a cohort of 18-year-olds born preterm and previously assessed at the age of 5.5.

Methods: We tested 134 adolescents born preterm with a very low birthweight of <1500g and 94 term-born controls with a comprehensive cognitive battery at 18years of age. The cohort was subdivided into 73 extremely preterm, 42 very preterm and 19 moderately preterm infants with gestational ages of 23-27, 28-31 and 32-36weeks, respectively. The moderately preterm group was dominated by adolescents born small for gestational age.

Results:Very preterm adolescents performed on a par with term-born controls. In contrast, extremely preterm adolescents displayed inferior results on all cognitive tests, more so if they had suffered neonatal complications. Moderately preterm adolescents scored lower than very preterm and full-term born adolescents, particularly on complex cognitive tasks.

Conclusion: Adolescents born at 28weeks of gestation or later, with appropriate birthweight and no perinatal complications, functioned like term-born peers at 18years of age. Extremely preterm birth per se posed a risk for long-term cognitive deficits, particularly executive deficits. Adolescents born moderately preterm but small for gestational age were at risk of general cognitive deficits.

Place, publisher, year, edition, pages
2015. Vol. 104, no 3, 292-299 p.
Keyword [en]
Adolescents, Long-term cognitive outcome, Medical complications, Preterm birth, Small for gestational age
National Category
Pediatrics Psychology
URN: urn:nbn:se:su:diva-115998DOI: 10.1111/apa.12864ISI: 000350062400022PubMedID: 25394225OAI: diva2:801886


Available from: 2015-04-10 Created: 2015-04-08 Last updated: 2015-04-10Bibliographically approved

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Smedler, Ann-Charlotte
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