Preparation of Tetrasubstituted Olefins Using Mono or Double Aerobic Direct C-H Functionalization Strategies: Importance of Steric Effects
2015 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 80, no 5, 2796-2803 p.Article in journal (Refereed) Published
A novel protocol for the synthesis of tetrasubstituted olefins through a biomimetic approach has been explored. Both mono- and diarylations were performed under ambient oxygen pressure, giving a range of highly hindered tetrasubstituted alkenes. For diarylation of disubstituted substrates, it was demonstrated that the second arylation is the rate-limiting step of the overall transformation.
Place, publisher, year, edition, pages
2015. Vol. 80, no 5, 2796-2803 p.
IdentifiersURN: urn:nbn:se:su:diva-116625DOI: 10.1021/acs.joc.5b00148ISI: 000350841600033PubMedID: 25653084OAI: oai:DiVA.org:su-116625DiVA: diva2:808190