Change search
ReferencesLink to record
Permanent link

Direct link
Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1
Show others and affiliations
2015 (English)In: Histology and Histopathology, ISSN 0213-3911, Vol. 30, no 3, 353-360 p.Article in journal (Refereed) Published
Abstract [en]

Age-related changes in mammalian hearts often result in cardiac hypertrophy and fibrosis that are preceded by inflammatory infiltration. In this paper, we show that lifelong treatment of BALB/c and C57BL/6 mice with the mitochondria-targeted antioxidant SkQ1 retards senescence-associated myocardial disease (cardiomyopathy), cardiac hypertrophy, and diffuse myocardial fibrosis. To investigate the molecular basis of the action of SkQ1, we have applied DNA microarray analysis. The global gene expression profile in heart tissues was not significantly affected by administration of SkQ1. However, we found some small but statistically significant modifications of the pathways related to cell-to-cell contact, adhesion, and leukocyte infiltration. Probably, SkQ1-induced decrease in leukocyte and mesenchymal cell adhesion and/or infiltration lead to a reduction in age-related inflammation and subsequent fibrosis. The data indicate a causative role of mitochondrial reactive oxygen species in cardiovascular aging and imply that SkQ1 has potential as a drug against age-related cardiac dysfunction.

Place, publisher, year, edition, pages
2015. Vol. 30, no 3, 353-360 p.
Keyword [en]
Mitochondria-targeted antioxidant, Myocardial fibrosis, Cardiac hypertrophy, Leukocyte infiltration
National Category
Biological Sciences Cell and Molecular Biology
URN: urn:nbn:se:su:diva-116534ISI: 000351203800009PubMedID: 25323729OAI: diva2:808371


Available from: 2015-04-28 Created: 2015-04-21 Last updated: 2015-04-28Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Shabalina, Irina G.
By organisation
Department of Molecular Biosciences, The Wenner-Gren Institute
In the same journal
Histology and Histopathology
Biological SciencesCell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 20 hits
ReferencesLink to record
Permanent link

Direct link