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Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Max Planck Institute for Human Development, Germany.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Umeå University, Sweden.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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2015 (English)In: Neuropsychology Review, ISSN 1040-7308, E-ISSN 1573-6660, Vol. 25, no 1, 47-62 p.Article, review/survey (Refereed) Published
Abstract [en]

Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from age-comparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.

Place, publisher, year, edition, pages
2015. Vol. 25, no 1, 47-62 p.
Keyword [en]
Aging, Functional brain imaging, Cognition, Genetics, APOE, BDNF, COMT, KIBRA
National Category
Psychology Neurology
Identifiers
URN: urn:nbn:se:su:diva-117514DOI: 10.1007/s11065-015-9279-8ISI: 000352822500004PubMedID: 25666727OAI: oai:DiVA.org:su-117514DiVA: diva2:812742
Note

AuthorCount:5;

Available from: 2015-05-20 Created: 2015-05-20 Last updated: 2017-12-04Bibliographically approved

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