Change search
ReferencesLink to record
Permanent link

Direct link
Genetics and Underlying Pathology of Dementia
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
2015 (English)In: Neuropsychology Review, ISSN 1040-7308, E-ISSN 1573-6660, Vol. 25, no 1, 113-124 p.Article, review/survey (Refereed) Published
Abstract [en]

As the population steadily ages, dementia, in all its forms, remains a great societal challenge. Yet, our knowledge of their etiology remains rather limited. To this end, genetic studies can give us insight into the underlying mechanisms that lead to the development of dementia, potentially facilitating treatments in the future. In this review we cover the most recent genetic risk factors associated with the onset of the four most common dementia types today, including Alzheimer's disease (AD), Vascular Dementia (VaD), Frontotemporal Lobar Degeneration (FTLD) and Lewy Body Dementia (LBD). Moreover, we discuss the overlap in major underlying pathologies of dementia derived from their genetic associations. While all four dementia types appear to involve genes associated with tau-pathology and neuroinflammation only LBD, AD and VaD appear to involve amyloid genes while LBD and FTLD share alpha synuclein genes. Together these findings suggest that some of the dementias may exist along a spectrum and demonstrates the necessity to conduct large-scale studies pinpointing the etiology of the dementias and potential gene and environment interactions that may influence their development.

Place, publisher, year, edition, pages
2015. Vol. 25, no 1, 113-124 p.
Keyword [en]
Genetics, Dementia, Alzheimer's disease, Lewy body dementia, Vascular dementia, Frontotemporal lobar degeneration
National Category
Neurosciences Psychology
URN: urn:nbn:se:su:diva-117394DOI: 10.1007/s11065-014-9276-3ISI: 000352822500007PubMedID: 25567624OAI: diva2:815292


Available from: 2015-05-29 Created: 2015-05-19 Last updated: 2015-05-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Aging Research Center (ARC), (together with KI)
In the same journal
Neuropsychology Review

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 11 hits
ReferencesLink to record
Permanent link

Direct link