Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia
2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 4, 434-443 p.Article in journal (Refereed) Published
Background: Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics. Methods: We investigated the associations between leisure-time physical activity (LTPA) from mid- to late life, the risk of dementia, and the role of body mass index, sex, and APOE in the CALDE study during 28-year follow-up. Cognitive function of a random subsample was assessed at a mean age of 78.8 years (n = 1511), and dementia/Alzheimer's disease (AD) diagnoses were identified from national registers for the entire target population (n = 3559). Results: Moderate (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.08-1.99) and low levels of midlife LTPA (BR, 1.39; 95% CI, 0.99-1.95) were associated with higher risk of dementia in comparison with the most active category. The benefits were more pronounced among men, overweight individuals, and APOE epsilon 4 noncarriers. Maintaining high LTPA (HR, 0.16; 95% CI, 0.06-0.41) or increasing LTPA (HR, 0.19; 95% CI, 0.09-0.40) after midlife was associated with lower dementia risk Similar results were observed for AD. Conclusions: The window of opportunity for preventive physical activity interventions may extend from midlife to older ages.
Place, publisher, year, edition, pages
2015. Vol. 11, no 4, 434-443 p.
Cohort study, Dementia, Exercise, Life course, Obesity, Physical activity
IdentifiersURN: urn:nbn:se:su:diva-117484DOI: 10.1016/j.jalz.2014.01.008ISI: 000353431800006PubMedID: 24721528OAI: oai:DiVA.org:su-117484DiVA: diva2:815517