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The Balbiani Ring Story: Synthesis, Assembly, Processing, and Transport of Specific Messenger RNA-Protein Complexes
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 2
2015 (English)In: Annual Review of Biochemistry, ISSN 0066-4154, E-ISSN 1545-4509, Vol. 84, 65-92 p.Article, review/survey (Refereed) Published
Abstract [en]

Eukaryotic gene expression is the result of the integrated action of multi-molecular machineries. These machineries associate with gene transcripts, often already nascent precursor messenger RNAs (pre-mRNAs). They rebuild the transcript and convey properties allowing the processed transcript, the mRNA, to be exported to the cytoplasm, quality controlled, stored, translated, and degraded. To understand these integrated processes, one must understand the temporal and spatial aspects of the fate of the gene transcripts in relation to interacting molecular machineries. Improved methodology is necessary to study gene expression in vivo for endogenous genes. A complementary approach is to study biological systems that provide exceptional experimental possibilities. We describe such a system, the Balbiani ring (BR) genes in polytene cells in the dipteran Chironomus tentans. The BR genes, along with their pre-mRNA-protein complexes (pre-mRNPs) and mRNA-protein complexes (mRNPs), allow the visualization of intact cell nuclei and enable analyses of where and when different molecular machineries associate with and act on the BR pre-mRNAs and mRNAs.

Place, publisher, year, edition, pages
2015. Vol. 84, 65-92 p.
Keyword [en]
gene expression, pre-mRNA processing, mRNA export, structure of mRNPs
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-119028DOI: 10.1146/annurev-biochem-060614-034150ISI: 000355765300005OAI: oai:DiVA.org:su-119028DiVA: diva2:843049
Available from: 2015-07-24 Created: 2015-07-24 Last updated: 2017-12-04Bibliographically approved

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Björk, PetraWieslander, Lars
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