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Reactivated herpes simplex infection increases the risk of Alzheimer's disease
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Umeå University, Sweden.
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Number of Authors: 5
2015 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 11, no 6, 593-599 p.Article in journal (Refereed) Published
Abstract [en]

Background: Previous studies have suggested a link between herpes simplex virus (HSV) type 1 and the development of Alzheimer's disease (AD). Methods: The present analysis included 3432 persons (53.9% women, mean age at inclusion 62.7 +/- 14.4 years) with a mean follow-up time of 11.3 years. The number of incident AD cases was 245. Serum samples were analyzed for anti-HSV antibodies (immunoglobulin (Ig)G and IgM) by enzyme-linked immunosorbent assays. Results: The presence of anti-HSV IgG antibodies was not associated with an increased risk for AD, controlled for age and sex (hazard ratio, HR, 0.993, P = .979). However, the presence of anti-HSV IgM at baseline was associated with an increased risk of developing AD (HR 1.959, P = .012). Conclusion: Positivity for anti-HSV IgM, a sign of reactivated infection, was found to almost double the risk for AD, whereas the presence of anti-HSV IgG antibodies did not affect the risk.

Place, publisher, year, edition, pages
2015. Vol. 11, no 6, 593-599 p.
Keyword [en]
Herpes, Herpes simplex, HSV, Alzheimer's disease, Dementia, Cohort study
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:su:diva-119244DOI: 10.1016/j.jalz.2014.04.522ISI: 000357231900002OAI: oai:DiVA.org:su-119244DiVA: diva2:846160
Available from: 2015-08-14 Created: 2015-08-03 Last updated: 2017-12-04Bibliographically approved

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