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RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
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2015 (English)In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 21, no 4, 314-317 p.Article in journal (Refereed) Published
Abstract [en]

Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

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2015. Vol. 21, no 4, 314-317 p.
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:su:diva-116951DOI: 10.1038/nm.3812ISI: 000352493600012PubMedID: 25751816OAI: oai:DiVA.org:su-116951DiVA: diva2:846549
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AuthorCount:21;

Available from: 2015-08-17 Created: 2015-05-04 Last updated: 2017-12-04Bibliographically approved

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Lara, Patriciavon Heijne, GunnarNilsson, IngMarie
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