RIFINs are adhesins implicated in severe Plasmodium falciparum malaria
2015 (English)In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 21, no 4, 314-317 p.Article in journal (Refereed) Published
Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), bind to RBCs-preferentially of blood group A-to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.
Place, publisher, year, edition, pages
2015. Vol. 21, no 4, 314-317 p.
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-116951DOI: 10.1038/nm.3812ISI: 000352493600012PubMedID: 25751816OAI: oai:DiVA.org:su-116951DiVA: diva2:846549