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First-Principles Investigation of Nanopore Sequencing Using Variable Voltage Bias on Graphene-Based Nanoribbons
Stockholm University, Nordic Institute for Theoretical Physics (Nordita). Los Alamos National Laboratory, New Mexico.
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Number of Authors: 5
2015 (English)In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 6, no 13, 2616-2621 p.Article in journal (Refereed) Published
Abstract [en]

In this study, we examine the mechanism of nanopore-based DNA sequencing using a voltage bias across a graphene nanoribbon. Using density function theory and a nonequilibrium Green's function approach, we determine the transmission spectra and current profile for adenine, guanine, cytosine, thymine, and uracil as a function of bias voltage in an energy minimized configuration. Utilizing the transmission current, we provide a general methodology for the development of a three nanopore graphene-based device that can be used to distinguish between the various nucleobases for DNA/RNA sequencing. From our analysis, we deduce that it is possible to use different transverse currents across a multinanopore device to differentiate between nucleobases using various voltages of 0.5, 1.3, and 1.6 V. Overall, our goal is to improve nanopore design to further DNA/RNA nucleobase sequencing and biomolecule identification techniques.

Place, publisher, year, edition, pages
2015. Vol. 6, no 13, 2616-2621 p.
National Category
Chemical Sciences Nano Technology Materials Engineering Physical Sciences
URN: urn:nbn:se:su:diva-119562DOI: 10.1021/acs.jpclett.5b01014ISI: 000357626700034OAI: diva2:846790
Available from: 2015-08-18 Created: 2015-08-17 Last updated: 2015-08-18Bibliographically approved

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Balatsky, Alexander V.
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Nordic Institute for Theoretical Physics (Nordita)
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