First-Principles Investigation of Nanopore Sequencing Using Variable Voltage Bias on Graphene-Based Nanoribbons
Number of Authors: 5
2015 (English)In: Journal of Physical Chemistry Letters, ISSN 1948-7185, E-ISSN 1948-7185, Vol. 6, no 13, 2616-2621 p.Article in journal (Refereed) Published
In this study, we examine the mechanism of nanopore-based DNA sequencing using a voltage bias across a graphene nanoribbon. Using density function theory and a nonequilibrium Green's function approach, we determine the transmission spectra and current profile for adenine, guanine, cytosine, thymine, and uracil as a function of bias voltage in an energy minimized configuration. Utilizing the transmission current, we provide a general methodology for the development of a three nanopore graphene-based device that can be used to distinguish between the various nucleobases for DNA/RNA sequencing. From our analysis, we deduce that it is possible to use different transverse currents across a multinanopore device to differentiate between nucleobases using various voltages of 0.5, 1.3, and 1.6 V. Overall, our goal is to improve nanopore design to further DNA/RNA nucleobase sequencing and biomolecule identification techniques.
Place, publisher, year, edition, pages
2015. Vol. 6, no 13, 2616-2621 p.
Chemical Sciences Nano Technology Materials Engineering Physical Sciences
IdentifiersURN: urn:nbn:se:su:diva-119562DOI: 10.1021/acs.jpclett.5b01014ISI: 000357626700034OAI: oai:DiVA.org:su-119562DiVA: diva2:846790