C-C Coupling of Ketones with Methanol Catalyzed by a N-Heterocyclic Carbene-Phosphine Iridium Complex
2015 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 21, 3576-3579 p.Article in journal (Refereed) Published
An N-heterocyclic carbene–phosphine iridium complex system was found to be a very efficient catalyst for the methylation of ketone via a hydrogen transfer reaction. Mild conditions together with low catalyst loading (1 mol %) were used for a tandem process which involves the dehydrogenation of methanol, CC bond formation with a ketone, and hydrogenation of the new generated double bond by iridium hydride to give the alkylated product. Using this iridium catalyst system, a number of branched ketones were synthesized with good to excellent conversions and yields.
Place, publisher, year, edition, pages
2015. Vol. 21, 3576-3579 p.
C[BOND]C coupling reactions, hydrogen transfer, iridium, ketones, methylation
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-119679DOI: 10.1002/chem.201405990ISI: 000350116200013OAI: oai:DiVA.org:su-119679DiVA: diva2:847683