Change search
ReferencesLink to record
Permanent link

Direct link
Influence of contaminated drinking water on perfluoroalkyl acid levels in human serum - A case study from Uppsala, Sweden
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. Helmholtz Centre for Environmental Research – UFZ, Germany.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Show others and affiliations
Number of Authors: 11
2015 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 140, 673-683 p.Article in journal (Refereed) Published
Abstract [en]

In 2012 a contamination of drinking water with perfluoroalkyl acids (PFAAs) was uncovered in the City of Uppsala, Sweden. The aim of the present study was to determine how these substances have been distributed from the contamination source through the groundwater to the drinking water and how the drinking water exposure has influenced the levels of PFAAs in humans over time. The results show that PFAA levels in groundwater measured 2012-2014 decreased downstream from the point source, although high Sigma PFAA levels (> 100 ng/L) were still found several kilometers from the point source in the Uppsala aquifer. The usage of aqueous film forming fire-fighting foams (AFFF) at a military airport in the north of the city is probably an important contamination source. Computer simulation of the distribution of PFAA-contaminated drinking water throughout the City using a hydraulic model of the pipeline network suggested that consumers in the western and southern parts of Uppsala have received most of the contaminated drinking water. PFAA levels in blood serum from 297 young women from Uppsala County, Sweden, sampled during 1996-1999 and 2008-2011 were analyzed. Significantly higher concentrations of perfluorobutane sulfonic acid (PFBS) and perfluorohexane sulfonic acid (PFHxS) were found among women who lived in districts modeled to have received contaminated drinking water compared to unaffected districts both in 1996-1999 and 2008-2011, indicating that the contamination was already present in the late 1990s. Isomer-specific analysis of PFHxS in serum showed that women in districts with contaminated drinking water also had an increased percentage of branched isomers. Our results further indicate that exposure via contaminated drinking water was the driving factor behind the earlier reported increasing temporal trends of PFBS and PFHxS in blood serum from young women in Uppsala.

Place, publisher, year, edition, pages
2015. Vol. 140, 673-683 p.
National Category
Earth and Related Environmental Sciences Health Sciences
URN: urn:nbn:se:su:diva-119744DOI: 10.1016/j.envres.2015.05.019ISI: 000357904100077OAI: diva2:849214
Available from: 2015-08-27 Created: 2015-08-24 Last updated: 2015-08-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Berger, Urs
By organisation
Department of Environmental Science and Analytical Chemistry
In the same journal
Environmental Research
Earth and Related Environmental SciencesHealth Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link