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Low dose effects of bisphenol A on the developing mammary gland - Combining new web-based tools to identify reliable and relevant data for regulatory risk assessment
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
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(English)Manuscript (preprint) (Other academic)
Abstract [en]

Background: Effects on the developing mammary gland have been repeatedly investigated and reported for bisphenol A (BPA) in experimental animals at doses close to or within human exposure range, and highlighted as being of potential concern to human health.

Objective: The present study provides a characterization of in vivo effects of BPA on the developing mammary gland in relation to the temporary tolerable daily intake (t-TDI), recently established by EFSA. The mammary gland data set was also used to explore the combined use of two different web-based tools for identifying sensitive and reliable data for risk assessment purposes.

Methods: The Health Assessment Workspace Collaborative (HAWC) was used for characterizing the mammary gland data in terms of type of effects investigated and reported and the distribution of these effects within the low dose range. The reliability of the mammary gland studies was evaluated using the Science in Risk Assessment and Policy (SciRAP) criteria. The results from HAWC and SciRAP were then combined to investigate whether there would be a shift in the type of effects reported and/or their distribution in the dose interval when considering only the studies judged as most reliable.

Results: No clear relationship could be identified between the reliability of the studies as assessed according to the SciRAP criteria and the type of mammary gland effects reported or their distribution within the low dose range, respectively.

Conclusions: The combined use of the HAWC and SciRAP tools would comprise a useful methodology for identifying reliable and sensitive information from in vivo toxicity studies of relevance to consider in the regulatory risk assessment process.  

Keyword [en]
bisphenol A, mammary gland, low dose effects, reliability evaluation, health risk assessment, SciRAP, HAWC
National Category
Environmental Sciences Environmental Health and Occupational Health
Research subject
Applied Environmental Science
Identifiers
URN: urn:nbn:se:su:diva-120328OAI: oai:DiVA.org:su-120328DiVA: diva2:851806
Available from: 2015-09-07 Created: 2015-09-07 Last updated: 2016-01-29Bibliographically approved
In thesis
1. Chemicals in consumer products: Bridging the gap between academic research and chemicals regulation
Open this publication in new window or tab >>Chemicals in consumer products: Bridging the gap between academic research and chemicals regulation
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Exposure to chemicals emitting from consumer products, such as clothes, electronic devices, toys and kitchen-ware, has emerged as an issue of public health and environmental concern. The use of chemicals having endocrine disrupting properties in commercial products is receiving particular attention as low dose exposures of such chemicals have been associated with adverse effects in both human and wildlife populations. Current chemicals regulation has been criticized for not providing adequate protection of human health and the environment with regard to consumer products. The aim of this thesis has been to provide new insights and methods related to the risk assessment and risk management of chemicals in consumer products in order to ensure a safer and more sustainable use.

The comparative analyses of different EU regulatory frameworks targeting the use of chemicals in articles identified a number of shortcomings and inconsistencies in how chemicals in articles are regulated. One main conclusion from Paper I was that product specific rules are important complements to REACH as they can more easily be tailored for certain uses and exposure scenarios. In Paper II it was investigated whether the regulation of chemicals in articles according to REACH is sufficient for meeting EU environmental goals, which include rectifying environmental problems at the source. It was concluded that the prioritization of substances to be targeted by restrictions and other requirements under REACH to a greater extent should take into account substances that have been identified as posing a risk to or via the environment.

With the aim to facilitate the use of all reliable and relevant toxicity information in regulatory health risk assessment of chemicals, a method for systematic and transparent evaluation of non-standard research studies, as well as reporting guidance for such studies, were developed in Paper III. It has for example been emphasized that non-standard research studies can provide valuable information with regard to endocrine disrupting effects. Such effects are not systematically tested for in standardized studies commonly preferred in regulatory risk assessments. In Paper IV, the method for study evaluation proposed in Paper III was combined with recently developed web-based tools that aid summarizing and visualizing toxicity data extracted from several studies. The combined use was found to comprise a promising methodology for identifying reliable and sensitive information from in vivo toxicity studies of relevance to consider in the risk assessment process.

The new methods and tools proposed and evaluated in this thesis will hopefully help improve the use of non-standard studies for risk assessment purposes and thereby strengthen the link between academic research and chemicals policy. In my view, this would be an important step towards improving public health protection with regard to the use of chemicals in consumer products.

Place, publisher, year, edition, pages
Department of Environmental Science and Analytical Chemistry, Stockholm University: Stockholm University, 2015. 42 p.
Keyword
consumer products, articles, chemicals, chemicals regulation, REACH, risk management, health risk assessment, non-standard toxicity studies, study evaluation, reporting guidance, endocrine disrupting compounds, bisphenol A, low dose effects
National Category
Environmental Sciences
Research subject
Applied Environmental Science
Identifiers
urn:nbn:se:su:diva-120285 (URN)978-91-7649-244-4 (ISBN)
Public defence
2015-10-06, Nordenskiöldsalen, Geovetenskapens hus, Svante Arrhenius väg 12, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Manuscript.

Available from: 2015-09-17 Created: 2015-09-04 Last updated: 2015-09-16Bibliographically approved

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