Potentially inappropriate drug use in older people: a nationwide comparison of different explicit criteria for population-based estimates
Number of Authors: 4
2015 (English)In: British Journal of Clinical Pharmacology, ISSN 0306-5251, E-ISSN 1365-2125, Vol. 80, no 2, 315-324 p.Article in journal (Refereed) Published
Aims: The aim was to investigate the prevalence of potentially inappropriate medication use among older people in Sweden according to five different published sets of explicit criteria from Europe and the US.
Methods: This was a nationwide cross-sectional, register-based study across the whole of Sweden in 2008. All individuals aged 65 years and older were included (n = 1 346 709, both community-dwelling and institutionalized persons). We applied all drug-specific criteria included in the 2012 Beers Criteria, the Laroche's list, the PRISCUS list, the NORGEP criteria and the Swedish National Board of Health and Welfare criteria. The main outcome was the potentially inappropriate drug use according to each set of criteria, separately and combined. Multivariate logistic regression models were used to identify individual factors associated with the use of potentially inappropriate drugs.
Results: The prevalence of potentially inappropriate medication use varied between the explicit criteria from 16% (NORGEP criteria) to 24% (2012 Beers criteria). Overall, 38% of the older people were exposed to potentially inappropriate drug use by at least one of the five sets of criteria. While controlling for other possible covariates, female gender, institutionalization and polypharmacy were systematically associated with inappropriate drug use, regardless of the set of explicit criteria we considered.
Conclusion: Although explicit criteria for inappropriate drug use among older people have been reported to be quite different in their content, they provide similar measures of the prevalence of potentially inappropriate drug use at the population level.
Place, publisher, year, edition, pages
2015. Vol. 80, no 2, 315-324 p.
inappropriate drug use, medications, older adults, pharmacoepidemiology
Gerontology, specializing in Medical and Health Sciences Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:su:diva-120065DOI: 10.1111/bcp.12615ISI: 000358445700017OAI: oai:DiVA.org:su-120065DiVA: diva2:852777