Enantioselective Synthesis of Chiral Sulfones by Ir-Catalyzed Asymmetric Hydrogenation: A Facile Approach to the Preparation of Chiral Allylic and Homoallylic Compounds
2012 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 134, no 33, 13592-13595 p.Article in journal (Refereed) Published
A highly efficient and enantioselective Ir-catalyzed hydrogenation of unsaturated sulfones was developed. Chiral cyclic and acyclic sulfones were produced in excellent enantioselectivities (up to 98% ee). Coupled with the Ramberg–Bäcklund rearrangement, this reaction offers a novel route to chiral allylic and homoallylic compounds in excellent enantioselectivities (up to 97% ee) and high yields (up to 94%).
Place, publisher, year, edition, pages
2012. Vol. 134, no 33, 13592-13595 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-120540DOI: 10.1021/ja306731uOAI: oai:DiVA.org:su-120540DiVA: diva2:853209