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Degree of abnormality is associated with rate of change in measures of beta-amyloid, glucose metabolism and cognition in an autopsy-verified Alzheimer’s disease case
Stockholm University, Faculty of Social Sciences, Department of Psychology. Karolinska Institutet, Sweden.
2015 (English)In: Neurocase, ISSN 1355-4794, E-ISSN 1465-3656, Vol. 21, no 6, 738-747 p.Article in journal (Refereed) Published
Abstract [en]

The degree of abnormality and rate of change in cognitive functions, positron emission tomography Pittsburg compound B (PET PIB), and fluorodeoxyglucose (FDG) measures were studied for 8 years in an autopsy-confirmed Alzheimer’s disease (AD) patient, who died 61 years old (Mini-Mental State Examination (MMSE) score 7). At first encounter with medical care, the patient was very mildly demented (MMSE score 27). She had four cognitive assessments and two examinations with PET PIB and FDG in 23 bilateral brain regions. The onset of cognitive decline was retrospectively estimated to have started in the early forties. The degree of impairment was inversely related to the rate of decline. A similar relationship was seen between the rate of change and the level of abnormality in both PIB and FDG. To conclude, rate of change in cognition, PIB, and FDG was associated with the degree of abnormality.

Place, publisher, year, edition, pages
2015. Vol. 21, no 6, 738-747 p.
Keyword [en]
Alzheimer’s disease, cognition, PET, PIB, FDG
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Research subject
URN: urn:nbn:se:su:diva-121090DOI: 10.1080/13554794.2014.979835ISI: 000373395300008OAI: diva2:855945
Available from: 2015-09-22 Created: 2015-09-22 Last updated: 2016-04-25Bibliographically approved

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Almkvist, Ove
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