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Bacteriophages and bacteriophage-derived endolysins as potential therapeutics to combat Gram-positive spore forming bacteria
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 3
2015 (English)In: Journal of Applied Microbiology, ISSN 1364-5072, E-ISSN 1365-2672, Vol. 119, no 3, 620-631 p.Article, review/survey (Refereed) Published
Abstract [en]

Since their discovery in 1915, bacteriophages have been routinely used within Eastern Europe to treat a variety of bacterial infections. Although initially ignored by the West due to the success of antibiotics, increasing levels and diversity of antibiotic resistance is driving a renaissance for bacteriophage-derived therapy, which is in part due to the highly specific nature of bacteriophages as well as their relative abundance. This review focuses on the bacteriophages and derived lysins of relevant Gram-positive spore formers within the Bacillus cereus group and Clostridium genus that could have applications within the medical, food and environmental sectors.

Place, publisher, year, edition, pages
2015. Vol. 119, no 3, 620-631 p.
Keyword [en]
Bacillus, bacteriophage, Clostridium, endolysin, phage therapy
National Category
Environmental Biotechnology Biological Sciences
URN: urn:nbn:se:su:diva-121504DOI: 10.1111/jam.12881ISI: 000360231000002OAI: diva2:860281
Available from: 2015-10-12 Created: 2015-10-05 Last updated: 2015-10-12Bibliographically approved

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Cooper, Callum J.
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Department of Molecular Biosciences, The Wenner-Gren Institute
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