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Magnified effects of the COMT gene on white-matter microstructure in very old age
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Max Planck Institute for Human Development, Germany.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Max Planck Institute for Human Development, Germany.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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Number of Authors: 10
2015 (English)In: Brain Structure and Function, ISSN 1863-2653, E-ISSN 1863-2661, Vol. 220, no 5, 2927-2938 p.Article in journal (Refereed) Published
Abstract [en]

Genetic factors may partly account for between-person differences in brain integrity in old age. Evidence from human and animal studies suggests that the dopaminergic system is implicated in the modulation of white-matter integrity. We investigated whether a genetic variation in the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism, which influences dopamine availability in prefrontal cortex, contributes to interindividual differences in white-matter microstructure, as measured with diffusion-tensor imaging. In a sample of older adults from a population-based study (60-87 years; n = 238), we found that the COMT polymorphism affects white-matter microstructure, indexed by fractional anisotropy and mean diffusivity, of several white-matter tracts in the oldest age group (81-87 years), although there were no reliable associations between COMT and white-matter microstructure in the two younger age groups (60-66 and 72-78 years). These findings extend previous observations of magnified genetic effects on cognition in old age to white-matter integrity.

Place, publisher, year, edition, pages
2015. Vol. 220, no 5, 2927-2938 p.
Keyword [en]
Aging, COMT, Dopamine, DTI, White-matter integrity
National Category
Gerontology, specializing in Medical and Health Sciences Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-121498DOI: 10.1007/s00429-014-0835-4ISI: 000360069200029OAI: oai:DiVA.org:su-121498DiVA: diva2:860583
Available from: 2015-10-13 Created: 2015-10-05 Last updated: 2017-12-01Bibliographically approved

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Brain Structure and Function
Gerontology, specializing in Medical and Health SciencesNeurosciences

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