Synthesis of Adjacent Quaternary Stereocenters by Catalytic Asymmetric Allylboration
Number of Authors: 4
2015 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 137, no 35, 11262-11265 p.Article in journal (Refereed) Published
Allylboration of ketones with gamma-disubstituted allylboronic acids is performed in the presence of chiral BINOL derivatives. The reaction is suitable for single-step creation of adjacent quaternary stereocenters with high selectivity. We show that, with an appropriate choice of the chiral catalyst and the stereoisomeric prenyl substrate, full control of the stereo- and enantioselectivity is possible in the reaction.
Place, publisher, year, edition, pages
2015. Vol. 137, no 35, 11262-11265 p.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-121788DOI: 10.1021/jacs.5b07498ISI: 000361251600015PubMedID: 26316158OAI: oai:DiVA.org:su-121788DiVA: diva2:861440