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Short-chain polyisoprenoids in the yeast Saccharomyces cerevisiae - New companions of the old guys
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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Number of Authors: 9
2015 (English)In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, ISSN 1388-1981, E-ISSN 1879-2618, Vol. 1851, no 10, 1296-1303 p.Article in journal (Refereed) Published
Abstract [en]

Dolichols are, among others, obligatory cofactors of protein glycosylation in eukaryotic cells. It is well known that yeast cells accumulate a family of dolichols with Dol-15/16 dominating while upon certain physiological conditions a second family with Dol-21 dominating is noted. In this report we identified the presence of additional short-chain length polyprenols - all-trans Pren-7 in three yeast strains (SS328, BY4741 and L5366), Pren-7 was accompanied by traces of putative Pren-6 and -8. Moreover, in two of these strains a single polyprenol mainly-cis-Pren-11 was synthesized at the stationary phase of growth. Identity of polyprenols was confirmed by HR-HPLC/MS, NMR and metabolic labeling. Additionally, simvastatin inhibited their biosynthesis.

Place, publisher, year, edition, pages
2015. Vol. 1851, no 10, 1296-1303 p.
Keyword [en]
Polyisoprenoid alcohols, Dolichol, Prenol, Saccharomyces cerevisiae, yeast
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-121859DOI: 10.1016/j.bbalip.2015.06.006ISI: 000361403100002PubMedID: 26143379OAI: oai:DiVA.org:su-121859DiVA: diva2:864227
Available from: 2015-10-26 Created: 2015-10-19 Last updated: 2017-12-01Bibliographically approved

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