Enantio- and Regioselective Hydrogenation of Minimally and Densely Decorated Unsaturated Carbocycles
(English)Manuscript (preprint) (Other academic)
Several cyclic prochiral olefins were successfully hydrogenated (>99 conv.,up to >99 % ee) using N,P-ligated iridium catalysts. Minimally functionalisedsubstrates (Class 1) were hydrogenated rapidly and in high ee, whichwas consistent with earlier reports. Substrates having functional groups(Class 2) and heterocycles (Class 3) attached to the unsaturated cycle, were43hydrogenated gradually over a period of time, however, high enantioselectivitywas still maintained (up to >99 % ee). This methodology is a highly practical,general and selective means of preparing chiral cyclohexanes.
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-122417OAI: oai:DiVA.org:su-122417DiVA: diva2:866086