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Equilibrium distributions and simulation methods for age structured populations
Stockholm University, Faculty of Science, Department of Mathematics.
Stockholm University, Faculty of Science, Department of Mathematics.
Number of Authors: 2
2015 (English)In: Mathematical Biosciences, ISSN 0025-5564, E-ISSN 1879-3134, Vol. 268, 45-51 p.Article in journal (Refereed) Published
Abstract [en]

A simulation method is presented for the demographic and genetic variation of age structured haploid populations. First, we use matrix analytic methods to derive an equilibrium distribution for the age class sizes conditioned on the total population size. Knowledge of this distribution eliminates the need of a burn-in time in simulations. Next, we derive the distribution of the alleles at a polymorphic locus in various age classes given the allele frequencies in the total population and the age size composition. For the time dynamics, we start by simulating the dynamics for the total population. In order to generate the inheritance of the alleles, we derive their distribution conditionally on the simulated population sizes. This method enables a fast simulation procedure of multiple loci in linkage equilibrium.

Place, publisher, year, edition, pages
2015. Vol. 268, 45-51 p.
Keyword [en]
Age structured population, Simulation method, Demographic variation, Genetic variation, Matrix analytic method
National Category
Biological Sciences Bioinformatics (Computational Biology) Mathematics
URN: urn:nbn:se:su:diva-122253DOI: 10.1016/j.mbs.2015.08.003ISI: 000362132800006OAI: diva2:866283
Available from: 2015-11-02 Created: 2015-10-28 Last updated: 2015-11-02Bibliographically approved

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Hössjer, Ola
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