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Serum 8-hydroxy-2'-deoxyguanosine (8-oxo-dG) levels are elevated in diabetes patients
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
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Number of Authors: 8
2015 (English)In: International Journal of Diabetes in Developing Countries, ISSN 0973-3930, E-ISSN 1998-3832, Vol. 35, no 3, 368-373 p.Article in journal (Refereed) Published
Abstract [en]

The increased oxidative stress in diabetes is known to contribute to the development of diabetes. We investigate whether serum 8-hydro-2'-deoxyguanosine (8-oxo-dG) is associated with diabetes at the time of first diagnosis and evaluate whether it can be used as a reliable biomarker for the oxidative stress in diabetes. The study was designed as a case control study with two groups: patient with diabetes and control. The diabetes group consisted of a total of 28 patients consulting the hospital for the first time and definitely diagnosed for diabetes, and the control group was composed of 65 healthy subjects. Serum 8-oxo-dG was measured by a competitive enzyme-linked immunosorbent assay (ELISA) kit, specially developed to minimize cross-reaction of 8-oxo-dG antibody with serum guanosine. The average serum 8-oxo-dG levels in patients with diabetes and controls were 0.72 +/- 0.41 and 0.24 +/- 0.14 ng/mL, respectively, statistically significant (p < 0.001). The 8-oxo-dG value was significantly higher in women with diabetes, compared with men with diabetes (p = 0.028). The sensitivity and the specificity of the 8-oxo-dG ELISA assay were 0.80 and 0.96, respectively, and the ROC value was 0.93. This study suggests that increased oxidative stress has an important role in the pathogenesis of diabetes. Serum 8-oxo-dG may be a useful clinical biomarker for the early diagnosis of stress-related diseases, e.g. diabetes and its management.

Place, publisher, year, edition, pages
2015. Vol. 35, no 3, 368-373 p.
Keyword [en]
Oxidative stress, 8-Oxo-dG, Diabetes
National Category
Cell Biology
Research subject
Molecular Bioscience
Identifiers
URN: urn:nbn:se:su:diva-122764DOI: 10.1007/s13410-015-0301-8ISI: 000363025800036OAI: oai:DiVA.org:su-122764DiVA: diva2:869040
Available from: 2015-11-12 Created: 2015-11-10 Last updated: 2017-08-10Bibliographically approved

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Sollazzo, AliceHarms-Ringdahl, MatsHaghdoost, Siamak
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