Change search
ReferencesLink to record
Permanent link

Direct link
The role of Alu elements in the cis-regulation of RNA processing
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 3
2015 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 72, no 21, 4063-4076 p.Article, review/survey (Refereed) Published
Abstract [en]

The human genome is under constant invasion by retrotransposable elements. The most successful of these are the Alu elements; with a copy number of over a million, they occupy about 10 % of the entire genome. Interestingly, the vast majority of these Alu insertions are located in gene-rich regions, and one-third of all human genes contains an Alu insertion. Alu sequences are often embedded in gene sequence encoding pre-mRNAs and mature mRNAs, usually as part of their intron or UTRs. Once transcribed, they can regulate gene expression as well as increase the number of RNA isoforms expressed in a tissue or a species. They also regulate the function of other RNAs, like microRNAs, circular RNAs, and potentially long non-coding RNAs. Mechanistically, Alu elements exert their effects by influencing diverse processes, such as RNA editing, exonization, and RNA processing. In so doing, they have undoubtedly had a profound effect on human evolution.

Place, publisher, year, edition, pages
2015. Vol. 72, no 21, 4063-4076 p.
Keyword [en]
Alu element, Retrotransposon, SINE, Exonization, RNA editing, circRNA, miRNA
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-122911DOI: 10.1007/s00018-015-1990-3ISI: 000363023200005OAI: oai:DiVA.org:su-122911DiVA: diva2:871940
Available from: 2015-11-17 Created: 2015-11-11 Last updated: 2015-11-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Daniel, ChammiranBehm, MikaelaÖhman, Marie
By organisation
Department of Molecular Biosciences, The Wenner-Gren Institute
In the same journal
Cellular and Molecular Life Sciences (CMLS)
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link