The role of Alu elements in the cis-regulation of RNA processing
Number of Authors: 3
2015 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 72, no 21, 4063-4076 p.Article, review/survey (Refereed) Published
The human genome is under constant invasion by retrotransposable elements. The most successful of these are the Alu elements; with a copy number of over a million, they occupy about 10 % of the entire genome. Interestingly, the vast majority of these Alu insertions are located in gene-rich regions, and one-third of all human genes contains an Alu insertion. Alu sequences are often embedded in gene sequence encoding pre-mRNAs and mature mRNAs, usually as part of their intron or UTRs. Once transcribed, they can regulate gene expression as well as increase the number of RNA isoforms expressed in a tissue or a species. They also regulate the function of other RNAs, like microRNAs, circular RNAs, and potentially long non-coding RNAs. Mechanistically, Alu elements exert their effects by influencing diverse processes, such as RNA editing, exonization, and RNA processing. In so doing, they have undoubtedly had a profound effect on human evolution.
Place, publisher, year, edition, pages
2015. Vol. 72, no 21, 4063-4076 p.
Alu element, Retrotransposon, SINE, Exonization, RNA editing, circRNA, miRNA
IdentifiersURN: urn:nbn:se:su:diva-122911DOI: 10.1007/s00018-015-1990-3ISI: 000363023200005OAI: oai:DiVA.org:su-122911DiVA: diva2:871940