Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Synthesis and DFT studies of an antitumor active spiro-oxindole
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Show others and affiliations
2015 (English)In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 39, no 10, 8017-8027 p.Article in journal (Refereed) Published
Abstract [en]

An anti-oncological active spiro-oxindole 7 was synthesized regioselectively via a [3+2]-cycloaddition reaction of azomethine ylide to exocyclic olefinic linkage of 4-piperidone 6, exhibiting properties against diverse tumor cell lines including leukemia, melanoma and cancers of the lung, colon, brain, ovary, breast, prostate, and kidney. Compound 7 crystallizes in the monoclinic system and P21/c space group with four molecules in the unit cell. The structure was also studied by AM1, PM3 and DFT techniques. DFT studies support the stereochemical selectivity of the reaction and determine the molecular electrostatic potential and frontier molecular orbitals.

Place, publisher, year, edition, pages
2015. Vol. 39, no 10, 8017-8027 p.
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-123211DOI: 10.1039/c5nj01109dISI: 000362355200068OAI: oai:DiVA.org:su-123211DiVA: diva2:872210
Available from: 2015-11-18 Created: 2015-11-18 Last updated: 2017-03-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Stawinski, Jacek
By organisation
Department of Organic Chemistry
In the same journal
New Journal of Chemistry
Organic Chemistry

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 29 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf