Self-Reported Memory Failures: Associations with Future Dementia in a Population-Based Study with Long-Term Follow-Up
Number of Authors: 4
2015 (English)In: Journal of The American Geriatrics Society, ISSN 0002-8614, E-ISSN 1532-5415, Vol. 63, no 9, 1766-1773 p.Article in journal (Refereed) Published
OBJECTIVES: To examine the association between self-reported memory failures and incident dementia in individuals aged 60 and older. DESIGN: Longitudinal, community based. SETTING: Betula Prospective Cohort Study, a population-based study in Umea, Sweden. PARTICIPANTS: Individuals with a mean age of 71.5 +/- 8.8 (range 60-90) (N = 1,547). MEASUREMENTS: Participants rated the frequency of everyday memory failures using the 16-item Prospective and Retrospective Memory Questionnaire (PRMQ) and underwent objective memory testing at baseline. Participant self-reports of complaints of poor memory by family and friends were evaluated. Dementia status was followed-up for 10 to 12 years. RESULTS: Over the study period, 225 participants developed dementia (132 with Alzheimer's disease (AD)). In Cox proportional hazard regression models adjusted for demographic factors, PRMQ z-scores predicted incident dementia (hazard ratio (HR) = 1.21 for all-cause dementia; HR = 1.25 for AD, Ps < .01). The significant associations remained when depressive symptoms and objective memory performance were adjusted for, when low performers on objective memory (= 1 standard deviations below the age group mean) were excluded, and in analyses with delayed entry (survival time = 5 years). Similar patterns were observed for the prospective and retrospective subscales, although including how often participants self-reported that others complained about their poor memory eliminated the association between PRMQ scores and dementia and itself emerged as a significant predictor. CONCLUSION: Self-reported memory failure predicted future dementia or AD independent of objective memory performance. Subjective reports of complaints by family and friends appear to be an even more-important indicator of preclinical impairments, and physicians should not ignore them, even in the absence of objective memory deficits.
Place, publisher, year, edition, pages
2015. Vol. 63, no 9, 1766-1773 p.
subjective memory, objective memory, dementia, Alzheimer's disease
IdentifiersURN: urn:nbn:se:su:diva-123349DOI: 10.1111/jgs.13611ISI: 000363804800005OAI: oai:DiVA.org:su-123349DiVA: diva2:874054