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Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents
Stockholm University, Faculty of Social Sciences, Centre for Health Equity Studies (CHESS). Karolinska Institutet, Sweden.
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2016 (English)In: European Archives of Psychiatry and Clinical Neuroscience, ISSN 0940-1334, E-ISSN 1433-8491Article in journal (Refereed) Epub ahead of print
Abstract

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.

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2016.
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Neurosciences Psychology
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URN: urn:nbn:se:su:diva-124105DOI: 10.1007/s00406-015-0664-3OAI: oai:DiVA.org:su-124105DiVA: diva2:882152
Available from: 2015-12-14 Created: 2015-12-14 Last updated: 2016-09-13

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af Klinteberg, Britt
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Centre for Health Equity Studies (CHESS)
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European Archives of Psychiatry and Clinical Neuroscience
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