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Aging-related magnification of genetic effects on cognitive and brain integrity
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Number of Authors: 3
2015 (English)In: Trends in cognitive sciences, ISSN 1364-6613, E-ISSN 1879-307X, Vol. 19, no 9, 506-514 p.Article, review/survey (Refereed) Published
Abstract [en]

Heritability studies document substantial genetic influences on cognitive performance and decline in old age. Increasing evidence shows that effects of genetic variations on cognition, brain structure, and brain function become stronger as people age. Disproportionate impairments are typically observed for older individuals carrying disadvantageous genotypes of different candidate genes. These data support the resource-modulation hypothesis, which states that genetic effects are magnified in persons with constrained neural resources, such as older adults.,However, given that findings are not unequivocal, we discuss the need to address several factors that may resolve inconsistencies in the extant literature (gene-gene and gene-environment interactions, study populations, gene-environment correlations, and epigenetic mechanisms).

Place, publisher, year, edition, pages
2015. Vol. 19, no 9, 506-514 p.
Keyword [en]
aging, cognition, genetics, brain structure, brain function
National Category
Psychology Basic Medicine Neurology
Identifiers
URN: urn:nbn:se:su:diva-121679DOI: 10.1016/j.tics.2015.06.008ISI: 000361165200008OAI: oai:DiVA.org:su-121679DiVA: diva2:889784
Available from: 2015-12-28 Created: 2015-10-13 Last updated: 2015-12-28Bibliographically approved

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ReferencesLink to record
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