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Leukocyte telomere length and hippocampus volume: a meta-analysis [version 1; referees: 2 approved]
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
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2015 (English)In: F1000 Research, ISSN 0106-3324, E-ISSN 2046-1402, Vol. 4, 1073Article, review/survey (Refereed) Published
Abstract [en]

Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and secondarily to investigate possible effect moderators. Five studies were included with a total of 2107 participants, of which 1960 were contributed by one single influential study. A random-effects meta-analysis estimated the effect to r = 0.12 [95% CI -0.13, 0.37] in the presence of heterogeneity and a subjectively estimated moderate to high risk of bias. There was no evidence that apolipoprotein E (APOE) genotype was an effect moderator, nor that the ratio of leukocyte telomerase activity to telomere length was a better predictor than leukocyte telomere length for hippocampus volume. This meta-analysis, while not proving a positive relationship, also is not able to disprove the earlier finding of a positive correlation in the one large study included in analyses. We propose that a relationship between leukocyte telomere length and hippocamus volume may be mediated by transmigrating monocytes which differentiate into microglia in the brain parenchyma.

Place, publisher, year, edition, pages
2015. Vol. 4, 1073
National Category
Gerontology, specializing in Medical and Health Sciences Applied Psychology
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URN: urn:nbn:se:su:diva-124556DOI: 10.12688/f1000research.7198.1PubMedID: 26674112Local ID: P-3298OAI: oai:DiVA.org:su-124556DiVA: diva2:889848
Available from: 2015-12-29 Created: 2015-12-29 Last updated: 2016-11-21Bibliographically approved

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Nilsonne, GustavTamm, SandraÅkerstedt, TorbjörnLekander, Mats
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