Change search
ReferencesLink to record
Permanent link

Direct link
Pre-existent anxiety symptoms is associated with modified behavioral response during endotoxemia
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
Stockholm University, Faculty of Social Sciences, Stress Research Institute.
Show others and affiliations
Number of Authors: 8
2015 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 49, e29-e30 p.Article in journal (Refereed) Published
Abstract [en]

Experimental endotoxin administration is a well-established model to analyze the effect of inflammation on the development of mood impairments. However, it remains unknown from previous studies in comparatively small samples whether pre-existing inter-individual differences modulate the behavioral response during endotoxemia. We addressed this question in the present study using a merged database combining data from multiple studies performed at two study sites. In 286 healthy volunteers who either received low-dose intravenous injection of lipopolysaccharide (LPS, 0.4–0.8 ng/kg, n = 168) or saline (n = 118), plasma concentrations of TNF-alpha and IL-6 were analyzed before and 2, 3.5 and 6 hours post injection together with state anxiety symptoms (STAI). Pre-existent symptoms of anxiety and depression (HADS) were assessed before injection. LPS administration induced an increase in state anxiety 2 hours post injection that was positively correlated with increases in TNF-alpha and IL-6, but not with pre-existent HADS scores (when adjusted for age, sex, BMI, LPS dose, and study design). However, higher levels of pre-existent HADS anxiety symptoms predicted a stronger subsequent reduction in state anxiety at 3.5 and 6 hours post LPS injection. Taken together, these data suggest that although inter-individual differences in anxiety or depression symptoms do not appear to explain the extent of mood impairments during endotoxemia, at least in non-patient samples, they still lead to a modified mood response with a faster and stronger decline.

Place, publisher, year, edition, pages
2015. Vol. 49, e29-e30 p.
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:su:diva-124562DOI: 10.1016/j.bbi.2015.06.118Local ID: P-3306OAI: oai:DiVA.org:su-124562DiVA: diva2:889871
Conference
The PsychoNeuroImmunology Research Society's 22nd Annual Scientific Meeting, Seattle, USA
Available from: 2015-12-29 Created: 2015-12-29 Last updated: 2016-06-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Lasselin, JulieLekander, MatsAxelsson, JohnKarshikoff, Bianca
By organisation
Stress Research Institute
In the same journal
Brain, behavior, and immunity
NeurosciencesNeurology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 14 hits
ReferencesLink to record
Permanent link

Direct link