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Recent in vivo advances in cell-penetrating peptide-assisted drug delivery
Stockholm University, Faculty of Science, Department of Neurochemistry.
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.
2016 (English)In: Expert Opinion on Drug Delivery, ISSN 1742-5247, E-ISSN 1744-7593, Vol. 13, no 3, 373-387 p.Article, review/survey (Refereed) Published
Abstract [en]

Introduction: Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo into the cytosol or nucleus. In addition to macromolecular delivery, CPPs have been used to deliver smaller bioactive molecules. Therefore CPPs have become an intensive field of research for medical treatment.

Areas covered: In this review, we highlight studies that include CPP in vivo disease models. We review different strategies and approaches that have been used, with specific attention on recent publications. The approaches that have been used include CPP–cargo covalent conjugation strategies and nanoparticle strategies. Various additional strategies have been used to achieve disease targeting, including active targeting, passive targeting, and combined active/passive strategies. As a result, delivery of various types of molecule has been achieved, including small drug molecules, proteins and nucleic acid-based macromolecules (e.g. siRNA, antisense nucleotides and plasmid DNA).

Expert Opinion: Despite recent advances in the field, confusions surrounding CPP internalization mechanisms and intracellular trafficking are hindering the development of new and more efficient vectors. Nevertheless, the recent increase in the number of publications containing in vivo CPP utilization looks promising that the number of clinical trials would also increase in the near future.

Place, publisher, year, edition, pages
2016. Vol. 13, no 3, 373-387 p.
Keyword [en]
CPP, in vivo delivery vectors, cell penetrating peptides, peptide vectors, Activatable CPP, drug delivery vectors
National Category
Medicinal Chemistry Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-124914DOI: 10.1517/17425247.2016.1125879ISI: 000370433900001PubMedID: 26634750OAI: oai:DiVA.org:su-124914DiVA: diva2:891231
Available from: 2016-01-06 Created: 2016-01-06 Last updated: 2016-03-14Bibliographically approved

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Gestin, MaximeLangel, Ülo
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