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The Antimicrobial and Antiviral Applications of Cell-Penetrating Peptides
Stockholm University, Faculty of Science, Department of Neurochemistry. Tartu University, Estonia.
2015 (English)In: Cell-Penetrating Peptides: Methods and Protocols / [ed] Ülo Langel, Springer-Verlag New York, 2015, Vol. 1324, 223-245 p.Chapter in book (Refereed)
Abstract [en]

Over the past two decades, cell-penetrating peptides (CPPs) have become increasingly popular both in research and in application. There have been numerous studies on the physiochemical characteristics and behavior of CPPs in various environments; likewise, the mechanisms of entry and delivery capabilities of these peptides have also been extensively researched. Besides the fundamental issues, there is an enormous interest in the delivery capabilities of the peptides as the family of CPPs is a promising and mostly non-toxic delivery vector candidate for numerous medical applications such as gene silencing, transgene delivery, and splice correction. Lately, however, there has been an emerging field of study besides the high-profile gene therapy applications-the use of peptides and CPPs to combat various infections caused by harmful bacteria, fungi, and viruses.In this chapter, we aim to provide a short overview of the history and properties of CPPs which is followed by more thorough descriptions of antimicrobial and antiviral peptides. To achieve this, we analyze the origin of such peptides, give an overview of the mechanisms of action and discuss the various practical applications which are ongoing or have been suggested based on research.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2015. Vol. 1324, 223-245 p.
, Methods in Molecular Biology, ISSN 1064-3745 ; 1324
Keyword [en]
CPP-cell-penetrating peptide, AMP-antimicrobial peptide, Tat, HIV, HCV
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:su:diva-124906DOI: 10.1007/978-1-4939-2806-4_15ISI: 000376037700016PubMedID: 26202273ISBN: 978-1-4939-2805-7ISBN: 978-1-4939-2806-4OAI: diva2:891240
Available from: 2016-01-06 Created: 2016-01-06 Last updated: 2016-06-20Bibliographically approved

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