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Classes of Cell-Penetrating Peptides.
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Stockholm University, Faculty of Science, Department of Neurochemistry. Laboratory of Molecular Biotechnology, Institute of Technology, Tartu University, Tartu, Estonia.
2015 (English)In: Cell-Penetrating Peptides: Methods and Protocols, Springer-Verlag New York, 2015, Vol. 1324, 3-28 p.Chapter in book (Refereed)
Abstract [en]

During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo. In parallel with application of CPPs for delivering of active payloads, the mechanisms that such peptides take advantage of for gaining access to cells' insides have been in the focus of intense studies. Although the common denominator "cell penetration" unites all CPPs, the interaction partners on the cell surface, evoked cellular responses and even the uptake mechanisms might greatly vary between different peptide types. Here we present some possibilities for classification of CPPs based on their type of origin, physical-chemical properties, and the extent of modifications and design efforts. We also briefly analyze the internalization mechanisms with regard to their classification into groups based on physical-chemical characteristics.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2015. Vol. 1324, 3-28 p.
Series
, Methods in Molecular Biology, ISSN 1064-3745 ; 1324
Keyword [en]
Cell-penetrating peptide, CPP classes, CPP kinetics, CPP mechanisms, Second-generation CPPs, Lipidated CPPs
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-124900DOI: 10.1007/978-1-4939-2806-4_1PubMedID: 26202259ISBN: 978-1-4939-2805-7ISBN: 978-1-4939-2806-4OAI: oai:DiVA.org:su-124900DiVA: diva2:891243
Available from: 2016-01-06 Created: 2016-01-06 Last updated: 2016-01-08Bibliographically approved

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Langel, Ülo
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Department of Neurochemistry
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