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Insulin/IGF signaling and its regulation in Drosophila
Stockholm University, Faculty of Science, Department of Zoology.
Stockholm University, Faculty of Science, Department of Zoology.
Stockholm University, Faculty of Science, Department of Zoology.
Number of Authors: 3
2015 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 221, 255-266 p.Article in journal (Refereed) Published
Abstract [en]

Taking advantage of Drosophila as a genetically tractable experimental animal much progress has been made in our understanding of how the insulin/IGF signaling (IS) pathway regulates development, growth, metabolism, stress responses and lifespan. The role of IIS in regulation of neuronal activity and behavior has also become apparent from experiments in Drosophila. This review briefly summarizes these functional roles of IIS, and also how the insulin producing cells (IPCs) are regulated in the fly. Furthermore, we discuss functional aspects of the spatio-temporal production of eight different insulin-like peptides (DILP1-8) that are thought to act on one known receptor (dInR) in Drosophila.

Place, publisher, year, edition, pages
2015. Vol. 221, 255-266 p.
Keyword [en]
Insulin, Insulin-like peptides, Drosophila melanogaster
National Category
Biological Sciences
Research subject
Functional Zoomorphology
Identifiers
URN: urn:nbn:se:su:diva-125036DOI: 10.1016/j.ygcen.2014.11.021ISI: 000364983100030PubMedID: 25616197OAI: oai:DiVA.org:su-125036DiVA: diva2:891770
Available from: 2016-01-07 Created: 2016-01-07 Last updated: 2016-01-12Bibliographically approved

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Nässel, Dick R.Liu, YitingLuo, Jiangnan
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